Cotyledon is a genus of succulent plants in the family Crassulaceae. Mostly from Southern Africa, they also occur throughout the drier parts of Africa as far north as the Arabian Peninsula. Members of the genus are shrublets, generally succulent, with fleshily woody, brittle stems and persistent succulent leaves. The leaves are opposite. Leaf pairs generally are oriented at 90 degrees to their preceding and following pairs, as is common in the family Crassulaceae, but the leaf habit differs from say Tylecodon (in which the leaves are borne in spirals and are deciduous). Most plants in the genus, and those that used to be included in the genus Cotyledon, are poisonous, even dangerously so. Some have been implicated in stock losses among goats, pigs and poultry. However, many species have long been used in traditional medicine. They have been applied for many purposes, ranging from magic charms to removal of corns.

This fast-growing succulent is well known to gardeners, forms a low shrub and adds colour to the winter garden. Forms with handsome grey leaves provide year-round interest in the garden. This succulent plant has thick leaves which may vary from green to grey, often with a red line around the margin. Cotyledon orbiculata has five varieties, based on differences in leaf and flower shape. The variability of leaf size, shape and colour is also influenced by the immediate environment. Selected forms in cultivation have been given names such as ‘Elk Horns’ or ‘Silver Waves’. Cotyledon orbiculata is widespread throughout South Africa, but is usually confined to rocky outcrops in grassland fynbos and Karoo regions. The brightly coloured flowers attract bees and birds, which feed on the nectar of the plant. The silver-grey leaves of some forms owe much of their attractive colouring to a powdery white coating which may assist in reflecting much of the sun’s heat to prevent excessive water loss from the thick succulent leaves. This is a well-known medicinal plant. The fleshy part of the leaf is applied by many South Africans to soften and remove hard corns and warts. The Southern Sotho uses a dried leaf as a protective charm for an orphan child and as a plaything. In the Willowmore District, the heated leaf is used as a poultice for boils and other accessible inflammations, in particular, earache. Van Wyk et al. (1997) report that a single leaf is eaten as a vermifuge and that the warmed juice can be used as drops for toothache or earache. They also report that the juice has been used to treat epilepsy.