Crossopteryx is a monospecific African genus with a wide distribution. The generic epithet is derived from Greek krossoi and pteron meaning fringed wing and is based on its seed shape. The specific epithet febrifuga relates to its medical use in fever treatment.

Crossopteryx febrifuga is a deciduous savanna tree 1.8-15 m tall, with a rounded crown and pendulous branchlets. Bark pale grey to dark brown, scaly, finely reticulate; young stems glabrous to densely hairy pubescent. Young leaves tender green.